User blog comment:Yoshijr/Viability Ranking if only based on usefulness/@comment-43507804-20200207134024/@comment-43507804-20200209001224

I can prove it, too.

At Rank 5, Santerion with 3 Level X Life runes has a Life stat of 319,350. If a Rank 5 Grumpex uses a completely unboosted (other than 3 Level X Strength Runes, of course) Lizard of Science, Not War on Santy, he deals a whopping 272,646 damage to him. And remember, while that doesn't insta-kill, it does leave Santy with only 46,704 Life left, and that's if he's max rank and all Level X runes.

Add in a monster that can add literally any damage booster (or deal 46,704 before Grumpex), and that's an OHKO. Add in any monster with a damage booster higher than Damage Boost (or is named Hornet), and he doesn't even need all 3 Level X Strength runes, so he can still have that TS to boost the denier.